Aspadol 100 contains the active ingredient Tapentadol, which is a centrally-acting analgesic medication used for the management of moderate to severe pain. Tapentadol works through a dual mechanism of action to alleviate pain:

Mu-Opioid Receptor Agonism: Tapentadol acts as an agonist at mu-opioid receptors in the brain and spinal cord. By binding to these receptors, Tapentadol inhibits the transmission of pain signals and alters the perception of pain. This opioid receptor activation leads to analgesia, or pain relief, by reducing the sensation of pain felt by the individual.

Norepinephrine Reuptake Inhibition: In addition to its opioid activity, Tapentadol also inhibits the reuptake of norepinephrine, a neurotransmitter involved in the regulation of pain signaling pathways. By increasing the concentration of norepinephrine in the central nervous system, Tapentadol enhances the inhibitory effects on pain transmission, resulting in further pain relief.

By combining opioid receptor agonism with norepinephrine reuptake inhibition, Tapentadol provides a dual mechanism of action that offers effective pain relief for a wide range of conditions, including neuropathic pain and musculoskeletal pain.